Which nerve supplies the webspace of the first and second toes?

The webspace between the first and second toes is primarily supplied by the medial branch of the deep peroneal nerve. This nerve enters the foot from the anterior compartment, running alongside the dorsalis pedis artery and providing sensory innervation to the skin in that region. The medial branch specifically targets the area between the first and second toes, allowing for sensation, which is crucial for balance and proprioception while walking or running.

The deep peroneal nerve is a branch of the common peroneal nerve, and it is responsible for innervating the muscles in the anterior compartment of the leg and the sensation in the webspace between the first and second toes. This anatomical relationship reinforces its role and confirms why it is the correct answer in this context.

Other nerves mentioned have different territories: the sural nerve primarily provides sensory innervation to the lateral aspect of the foot and the heel, while the tibial nerve supplies the plantar aspect of the foot, and the superficial peroneal nerve innervates the lateral aspect of the lower leg and the dorsum of the foot, not the area between the first and second toes.