Which genetic condition is commonly associated with duodenal atresia?

Duodenal atresia is a congenital condition where a part of the intestine, specifically the duodenum, fails to develop properly, leading to a blockage. This condition is often identified in newborns and is characterized by the "double bubble" sign seen on an X-ray due to trapped air in the stomach and proximal duodenum.

Down's syndrome, or Trisomy 21, is commonly associated with various congenital anomalies, including gastrointestinal defects such as duodenal atresia. The correlation between Down's syndrome and duodenal atresia is significant; studies have shown that a notable percentage of infants born with Down's syndrome also present with this condition. This association is important for clinicians, as it prompts them to look for additional congenital issues when a diagnosis of Down's syndrome is made.

The other conditions listed, while they have their own sets of associated anomalies, do not have a strong association with duodenal atresia as seen in Down's syndrome. Turner syndrome, Patau syndrome, and Edward's syndrome each have distinct clinical presentations and associated defects, but duodenal atresia is most frequently noted in infants with Down's syndrome, making it the most recognized genetic condition linked to this specific gastrointestinal malformation