Which anaesthetics are noted to cause myocardial depression?

The choice identifying propofol and sodium thiopentone as anaesthetics that can cause myocardial depression is correct for several reasons related to their pharmacological effects on the cardiovascular system.

Propofol is a commonly used intravenous anaesthetic known for its rapid onset and short duration of action. One of its significant side effects is myocardial depression. When administered, propofol causes vasodilation, leading to a decrease in systemic vascular resistance and a subsequent drop in blood pressure. This cardiovascular effect can result in a decreased cardiac output, especially in patients who may already be hemodynamically compromised.

Sodium thiopentone, another intravenous anaesthetic, also has a notable impact on cardiac function. Although it primarily acts as a barbiturate, it similarly causes vasodilation and may depress myocardial contractility. The administration of this drug can lead to hypotension due to diminished cardiac output and peripheral vascular resistance, especially in higher doses or in sensitive populations.

The combination of these two agents typically results in a greater risk of myocardial depression compared to other anaesthetics mentioned within the other options. Understanding the cardiovascular side effects of various anaesthetics is critical for maintaining patient safety during surgical procedures, especially in patients with pre-existing cardiac conditions.

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