Which anaesthetic is associated with hepatotoxicity?

Halothane is the anaesthetic associated with hepatotoxicity, primarily due to its potential to induce halothane hepatitis. This condition arises when halothane is metabolized by the liver and produces trifluoroacetylated proteins, which can trigger an immune response leading to liver damage. This adverse effect is particularly significant in individuals who have been exposed to halothane multiple times, as repeated exposure increases the risk of developing hepatic injury.

In contrast, other anaesthetic agents listed, such as desflurane and sevoflurane, are considered to have minimal impact on liver function and do not have a well-documented association with hepatotoxicity. Propofol is primarily an intravenous anesthetic that is not linked to liver toxicity in the same manner as halothane, making it safer regarding hepatic effects. Understanding the specific side effects associated with each anesthetic agent is crucial for ensuring patient safety during surgical procedures.