What type of lesions are indicative of granulomatous diseases like Granulomatosis with polyangiitis?

What type of lesions are indicative of granulomatous diseases like Granulomatosis with polyangiitis?

• A. Hemorrhagic lesions
• B. Granulomatous lesions
• C. Ulcerative lesions
• D. Fibrotic lesions

Answer: (B)

Granulomatous lesions are characteristic of granulomatous diseases such as Granulomatosis with polyangiitis, which is also known as Wegener's granulomatosis. In these conditions, the immune system forms granulomas, which are small aggregates of macrophages that fuse to become multinucleated giant cells, along with other immune cells. This is a specific response to persistent inflammation, often triggered by infections, autoimmune processes, or foreign materials. Granulomatous lesions are typically found affecting various organs, including the lungs, kidneys, and sinuses, and they can manifest in a variety of ways depending on the location and severity of the inflammation. The presence of these lesions is critical in diagnosing granulomatous diseases, as they signify a chronic inflammatory process. In contrast, the other types of lesions mentioned do not accurately reflect the histopathological findings in granulomatous diseases. Hemorrhagic lesions imply bleeding or hemorrhage, ulcerative lesions relate to tissue loss or ulcers rather than granuloma formation, and fibrotic lesions involve scar tissue formation due to chronic inflammation or damage but do not typically involve the granulomatous inflammation associated with the disease in question.

Granulomatous lesions are characteristic of granulomatous diseases such as Granulomatosis with polyangiitis, which is also known as Wegener's granulomatosis. In these conditions, the immune system forms granulomas, which are small aggregates of macrophages that fuse to become multinucleated giant cells, along with other immune cells. This is a specific response to persistent inflammation, often triggered by infections, autoimmune processes, or foreign materials.

Granulomatous lesions are typically found affecting various organs, including the lungs, kidneys, and sinuses, and they can manifest in a variety of ways depending on the location and severity of the inflammation. The presence of these lesions is critical in diagnosing granulomatous diseases, as they signify a chronic inflammatory process.

In contrast, the other types of lesions mentioned do not accurately reflect the histopathological findings in granulomatous diseases. Hemorrhagic lesions imply bleeding or hemorrhage, ulcerative lesions relate to tissue loss or ulcers rather than granuloma formation, and fibrotic lesions involve scar tissue formation due to chronic inflammation or damage but do not typically involve the granulomatous inflammation associated with the disease in question.