What is the APTT result for a patient with Hemophilia?

In a patient with Hemophilia, the APTT (activated Partial Thromboplastin Time) is typically prolonged, which corresponds to a high APTT result. Hemophilia is primarily caused by deficiencies in clotting factors (factor VIII in Hemophilia A and factor IX in Hemophilia B), which play crucial roles in the intrinsic pathway of the coagulation cascade. APTT is specifically designed to assess this pathway, and when there is a deficiency in these factors due to Hemophilia, the time it takes for blood to clot is increased, resulting in a high APTT value.

In contrast, conditions or scenarios that maintain normal clotting factor levels would present with a normal APTT, while a low APTT would indicate increased clotting activity, generally not seen in hemophilia. Variations in APTT results could occur due to other factors or comorbid conditions, but the characteristic finding in hemophilia is a significantly prolonged APTT. Therefore, a high APTT result correctly reflects the underlying pathology of Hemophilia.