What is a significant clinical feature of Pemphigus vulgaris?

Pemphigus vulgaris is primarily characterized by the formation of painful blisters and erosions on mucous membranes, as well as the skin. This autoimmune condition results in the disruption of adhesion between keratinocytes due to antibodies that target desmosomal proteins, leading to the clinical manifestation of flaccid blisters. These blisters are often fragile and can easily rupture, resulting in erosions that can be found in various locations, including the oral cavity, which is a hallmark feature of the disease.

While the other options present some features that may be observed in various skin conditions, they do not specifically align with the defining characteristics of Pemphigus vulgaris. Excessive sweating is not a primary symptom, skin peeling might suggest other dermatological conditions, and yellowish skin discoloration typically points towards conditions like jaundice rather than Pemphigus vulgaris. Thus, the presence of blisters and erosions on mucous membranes stands out as the significant clinical feature of this specific autoimmune dermatological disease.