What is a significant clinical feature of Pemphigus vulgaris?

Pemphigus vulgaris is a serious autoimmune blistering disorder characterized by the formation of blisters and erosions primarily on the mucous membranes and skin. The hallmark feature of this condition is the presence of painful, flaccid blisters that can easily rupture, leading to erosive lesions. These blisters often occur in areas such as the oral cavity, which is a prominent aspect of the disease, as well as on the skin.

In the context of the other options, excessive sweating is not typically associated with pemphigus vulgaris. Skin peeling may occur, but it is not as specific or definitive as the characteristic blisters and erosions. Yellowish skin discoloration can indicate various other conditions, such as jaundice, but it is not a direct feature of pemphigus vulgaris. Therefore, the most significant and specific clinical feature of this condition is indeed the presence of blisters and erosions on mucous membranes.