What is a common feature of linitis plastica on histological examination?

Linitis plastica, a diffuse type of gastric adenocarcinoma, is characterized histologically by the presence of signet ring cells. These are atypical glandular cells that are indicative of a more advanced and aggressive form of the disease. Signet ring cells contain abundant mucin within their cytoplasm, which displaces the nucleus to the periphery, giving them their distinctive appearance. This histological feature reflects the nature of linitis plastica, where the cancer typically infiltrates the gastric wall, leading to the characteristic rigidity and thickening of the stomach wall.

While necrosis, fibrous tissue, and ulceration may be present in various forms of gastric cancer or other pathological conditions, they are not defining features of linitis plastica. The specific identification of signet ring cells is crucial in diagnosing this type of cancer and differentiating it from other gastric cancers, thereby making this the most relevant and distinguishing histological feature.