What condition may cause necrolytic migratory erythema?

Necrolytic migratory erythema is a distinctive skin condition characterized by erythematous plaques with blistering and scaling, often associated with underlying metabolic disorders. It is classically linked to glucagonoma, which is a rare type of pancreatic neuroendocrine tumor that secretes excessive amounts of glucagon.

In patients with glucagonoma, the overproduction of glucagon leads to a variety of symptoms, including weight loss, diabetes mellitus, and the characteristic skin rash known as necrolytic migratory erythema. This condition typically appears on areas of the skin subject to friction or pressure, such as the groin, buttocks, and axillae. The skin lesions can be very itchy and may evolve over time, presenting with a distinct migratory pattern.

Other conditions listed, while they may have their own associated skin manifestations or metabolic effects, do not specifically lead to necrolytic migratory erythema in the way that glucagonoma does. For instance, pancreatic adenocarcinoma primarily manifests with symptoms related to the cancer itself rather than specific skin findings. Small bowel obstruction and chronic pancreatitis also do not directly cause this particular rash. Understanding glucagonoma and its relationship with necroly