What characterizes comedo necrosis on core biopsy?

Comedo necrosis is a pathological finding typically associated with certain types of breast carcinoma, most notably in high-grade ductal carcinoma in situ (DCIS) and invasive breast cancer. It is characterized by the presence of necrotic tissue that can become calcified. The term "comedo" refers to the appearance of these necrotic areas, which resemble comedones or clogged hair follicles.

The correct choice highlights that necrosis is accompanied by calcifications, which is a common feature seen in histological examinations of cancers exhibiting comedo necrosis. These calcifications arise as a result of the degeneration and cellular death in the necrotic areas, often reflecting the underlying malignancy's aggressive behavior.

In contrast, while the presence of blood can sometimes be observed in tissues affected by necrosis, it is not a defining characteristic of comedo necrosis itself. Non-neoplastic lesions are not relevant to comedo necrosis, as the term is specifically associated with neoplastic processes. Lastly, fluid-filled cysts are indicative of other types of lesions or benign conditions and do not align with the features of comedo necrosis, which is defined by necrotic tissue and calcifications. Therefore, the identification of necrosis with accompanying calcifications