Thiazide diuretics primarily act on which part of the nephron?

Thiazide diuretics primarily target the distal convoluted tubule of the nephron. This segment of the nephron is responsible for the reabsorption of sodium and chloride, which thiazide diuretics inhibit. By blocking the sodium-chloride co-transporter in this region, thiazides lead to increased excretion of sodium and water, resulting in diuresis.

This mechanism is pivotal in the management of conditions such as hypertension and edema, as it effectively helps to reduce fluid retention and lower blood pressure. Understanding the site of action for thiazide diuretics is essential for comprehending how they influence fluid balance and electrolyte levels in the body.