In disseminated intravascular coagulation (DIC), which factors are impacted?

In disseminated intravascular coagulation (DIC), there is widespread activation of the coagulation cascade, leading to the consumption of clotting factors and platelets. The correct choice includes factors that are directly affected during this process due to excessive clot formation and subsequent breakdown.

The factors listed in the correct answer include Factor I (Fibrinogen), Factor II (Prothrombin), Factor V, Factor VIII, and Factor XI. In DIC, fibrinogen is consumed as it is converted to fibrin to form clots throughout the circulation. Prothrombin is also utilized in the clotting process, and the factors involved in the intrinsic pathway, such as Factor V and Factor VIII, are crucial for thrombin generation and fibrin formation. Factor XI contributes to the intrinsic pathway of coagulation, which can also be activated in DIC.

The impact on these factors is significant because as they are consumed, there is a depletion that can lead to a coagulopathic state, characterized by both bleeding and thrombosis, which is a hallmark of DIC. This understanding reflects the multifaceted nature of this condition and highlights the importance of recognizing which factors are most impacted during the pathological process.

The incorrect choices contain factors that are